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  • The U.S. Food and Drug Administration has approved Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) as treatment selection for chronic weight reduction in addition to a reduced-calorie diet and exercise.

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    Researchers found out that participants investing in this drug for any year, dropped excess weight within four weeks and have kept the load off through the 56 weeks of the study. Contrave is often a combination of the drugs naltrexone and bupropion, which generally seems to reflect a fresh trend of weight-loss drugs which can be made up of more than one active ingredient, which may make them more potent and safer.

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    Seizures can be a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug can also raise blood pressure level and heartrate, and must not be used in people who have a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with all the drug.

    The FDA also warned that Contrave can raise blood pressure and heartrate and must stop used in patients with uncontrolled high blood pressure levels, as well as by you aren't heart-related and cerebrovascular (blood vessel dysfunction impacting the brain) disease. Patients using a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert medical professionals and patients on the increased chance of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for smoking cessation.

    From a psychiatric viewpoint, evidence implies that the ordinary neural mechanism for goal-directed behavior has been hijacked from the addiction, and malfunctions so that its ordinary functions are exaggerated and fixated on its object. An object generates a stimulus as well as the person engages in a "goal-directed behavioral response" that generates a "natural high"(Bostwick & Bucci, 2008).